Study: Human blood stem cells age faster in space (UCSD)
Human blood stem cells show signs of accelerated aging after a month in space A University of California San Diego–led study found that human hematopoietic stem and progenitor cells (HSPCs) exposed to 32–45 days aboard the International Space Station displayed signs of accelerated molecular aging. Changes included reduced self-renewal capacity, increased DNA damage, mitochondrial inflammation, shortened telomeres, and activation of normally silent genomic elements. Importantly, many of these effects were at least partially reversible after the cells returned to Earth. “Space is the ultimate stress test for the human body,” said Catriona Jamieson, director of the UC San Diego Sanford Stem Cell Institute. “These findings ... show that the stressors of space — like microgravity and cosmic galactic radiation — can accelerate the molecular aging of blood stem cells.” How…
